期刊
CURRENT OPINION IN CELL BIOLOGY
卷 23, 期 4, 页码 370-376出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2011.05.003
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资金
- Chemical Sciences, Geosciences and Biosciences Division, Office of Basic Energy Sciences, of the U.S. Department of Energy [DE-AC02-05CH11231]
- National Cancer Institute (NCI) [U54 CA143836]
Large-scale molecular assemblies, or signaling clusters, at the cell membrane are emerging as important regulators of cell signaling. Here, we review new findings and describe shared characteristics common to signaling clusters from a diverse set of cellular systems. The well-known T cell receptor cluster serves as our paradigmatic model. Specifically, each cluster initiates recruitment of hundreds of molecules to the membrane, interacts with the actin cytoskeleton, and contains a significant fraction of the entire signaling process. Probed by recent advancements in patterning and microscopy techniques, the signaling clusters display functional outcomes that are not readily predictable from the individual components.
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