期刊
CURRENT OPINION IN CELL BIOLOGY
卷 22, 期 2, 页码 226-233出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2009.11.003
关键词
-
类别
资金
- U.S. Public Health Service [CA140964, AI083841]
- Leukemia & Lymphoma Society of USA
- Wright Foundation
- Baxter Foundation
- Fletcher Jones Foundation
- Hastings Foundation
- Korean GRL Program [K20815000001]
- [CA82057]
- [CA91819]
- [CA31363]
- [CA115284]
- [A1073099]
Autophagy, originally described as a universal lysosome-dependent bulk degradation of cytoplasmic components upon nutrient deprivation, has since been shown to influence diverse aspects of homeostasis and is implicated in a wide variety of pathological conditions, including cancer. The list of autophagy-related (Atg) genes associated with the initiation and progression of human cancer as well as with responses to cancer therapy continues to grow as these genes are being discovered. However, whether Atg genes work through their expected mechanisms of autophagy regulation and/or through as-yet-undefined functions in the development of cancer remains to be further clarified. Here we review recent advances in the knowledge of the molecular basis of autophagy genes and their biological outputs during tumor development. A better understanding of the mechanistic link between cellular autophagy and tumor growth control may ultimately better human cancer treatments.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据