期刊
CURRENT OPINION IN CELL BIOLOGY
卷 21, 期 6, 页码 778-784出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2009.10.004
关键词
-
类别
资金
- NIGMS NIH HHS [R01 GM076186] Funding Source: Medline
Genome rearrangements are important in pathology and evolution. The thesis of this review is that the genome is in peril when replication forks stall, and stalled forks are normally rescued by error-free mechanisms. Failure of error-free mechanisms results in large-scale chromosome changes called gross chromosomal rearrangements, GCRs, by the aficionados. In this review we discuss five error-free mechanisms a replication fork may use to overcome blockage, mechanisms that are still poorly understood. We then speculate on how genome rearrangements may occur when such mechanisms fail. Replication fork recovery failure may be an important feature of the oncogenic process. (Feedback to the authors on topics discussed herein is welcome.)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据