期刊
CURRENT OPINION IN CELL BIOLOGY
卷 21, 期 6, 页码 741-747出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2009.10.003
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资金
- NICHD NIH HHS [R01 HD030830, R01 HD051936, R21 HD044915] Funding Source: Medline
- NIDDK NIH HHS [R01 DK067826, R21 DK061802] Funding Source: Medline
The rhombic lip (aka rautenlippe) is a germinative neuroepithelium rimming the opening of the hindbrain fourth ventricle during development. Studies spanning more than a century have shown that the rhombic lip produces numerous brainstem neuronal populations unique in their development and functions. While these studies have largely been anatomical in nature, recent applications of newer techniques such as genetic fate mapping and conditional mutagenesis have resolved the rhombic lip into numerous molecularly distinct progenitor domains along spatial and temporal axes that give rise to specific neuron subtypes and systems. This exciting convergence between anatomical and molecular definitions of the rhombic lip and its constituent progenitor populations provides now an important framework for further studies into the genetic basis of development and function of numerous hindbrain neuron types crucial to life.
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