期刊
CURRENT OPINION IN CELL BIOLOGY
卷 20, 期 5, 页码 525-532出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2008.04.003
关键词
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类别
资金
- The Linda Jacobs Chair in Immune and Stem Cell Research
- Israel Science Foundation
- Minerva foundation
- MAIN
- EU6 Program for Migration in Inflammation
- Public Health Service: National Institutes of Health
The arrest of rolling leukocytes on various target vascular beds is mediated by specialized leukocyte integrins and their endothelial immunoglobulin superfamily (IgSF) ligands. These integrins are kept in largely inactive states and undergo in situ activation upon leukocyte-endothelial contact by both biochemical and mechanical signals from flow-derived shear forces. In vivo and in vitro studies suggest that leukocyte integrin activation involves conformational alterations through inside-out signaling followed by ligand-induced rearrangements accelerated by external forces. This activation process takes place within fractions of seconds by in situ signals transduced to the rolling leukocyte as it encounters specialized endothelial-displayed chemoattractants, collectively termed arrest chemokines. In neutrophils, selectin rolling engagements trigger intermediate affinity integrins to support reversible adhesions before chemokine-triggered arrest. Different leukocyte subsets appear to use different modalities of integrin activation during rolling and arrest at distinct endothelial sites.
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