期刊
CURRENT OPINION IN CELL BIOLOGY
卷 20, 期 3, 页码 294-302出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2008.03.006
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资金
- NIDDK NIH HHS [R01 DK069710-01, R56 DK069710-04, R01 DK069710, R56 DK069710, R01 DK069710-02, R01 DK069710-03] Funding Source: Medline
The regulation of gene expression requires a wide array of protein factors that can modulate chromatin structure, act at enhancers, function as transcriptional coregulators, or regulate insulator function. Poly(ADP-ribose) pblymerase-1 (PARP-1), an abundant and ubiquitous nuclear enzyme that catalyzes the NAD(+)-dependent addition of ADP-ribose polymers on a variety of nuclear proteins, has been implicated in all of these functions. Recent biochemical, genomic, proteomic, and cell-based studies have highlighted the role of PARP-1 in each of these processes and provided new insights about the molecular mechanisms governing PARP-1-dependent regulation of gene expression. In addition, these studies have demonstrated how PARP-1 functions as an integral part of cellular signaling pathways that culminate in gene-reguiatory outcomes.
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