期刊
CURRENT OPINION IN CELL BIOLOGY
卷 20, 期 2, 页码 119-125出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2008.01.009
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资金
- NIGMS NIH HHS [R01 GM074241-03, R01 GM074241] Funding Source: Medline
Wnt/beta-catenin signaling has central roles in embryogenesis and human diseases including cancer. A central scheme of the Writ pathway is to stabilize the transcription coactivator beta-catenin by preventing its phosphorylation-dependent degradation. Significant progress has been made toward the understanding of this crucial regulatory pathway, including the protein complex that promotes beta-catenin phosphorylation-degradation, and the mechanism by which the extracellular Writ ligand engages cell surface receptors to inhibit beta-catenin phosphorylation-degradation. Here we review some recent discoveries in these two areas, and highlight some crucial questions that remain to be resolved.
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