期刊
CURRENT OPINION IN CELL BIOLOGY
卷 20, 期 1, 页码 101-106出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2007.11.004
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资金
- NIGMS NIH HHS [GM 51542, R01 GM051542, R01 GM051542-11, R37 GM051542] Funding Source: Medline
Chromosome alignment and segregation during cell division rely on a highly ordered bipolar microtubule array called the mitotic spindle. The organization of microtubules into bipolar spindles with focused poles during mitosis requires numerous microtubule-associated proteins including both motor and nonmotor proteins. Nonmotor microtubule-associated proteins display extraordinary diversity in how they contribute to mitotic spindle organization. These mechanisms include regulation of microtubule nucleation and organization, direct and indirect influences on motor function, and control of cell cycle progression. Furthermore, many nonmotor spindle proteins display altered expression in cancer cells emphasizing their important roles in cell proliferation.
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