期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 30, 期 -, 页码 230-237出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2014.09.002
关键词
-
资金
- National Institutes of Health [GM077596]
- National Academies Keck Futures Initiative on Synthetic Biology
Natural products have been and continue to be the source and inspiration for a substantial fraction of human therapeutics. Although the pharmaceutical industry has largely turned its back on natural product discovery efforts, such efforts continue to flourish in academia with promising results. Natural products have traditionally been identified from a top-down perspective, but more recently genomics- and bioinformatics-guided bottom-up approaches have provided powerful alternative strategies. Here we review recent advances in natural product discovery from both angles, including diverse sampling and innovative culturing and screening approaches, as well as genomics-driven discovery and genetic manipulation techniques for both native and heterologous expression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据