期刊
JOURNAL OF NEUROSCIENCE
卷 35, 期 28, 页码 10168-10171出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0524-15.2015
关键词
aspartate; glutamate; neurotransmitter; sialin; VGLUT1
资金
- National Institute of Mental Health-National Institutes of Health
- National Institute on Drug Abuse
- Fondation Fyssen
Recent evidence has resurrected the idea that the amino acid aspartate, a selective NMDA receptor agonist, is a neurotransmitter. Using a mouse that lacks the glutamate-selective vesicular transporter VGLUT1, we find that glutamate alone fully accounts for the activation of NMDA receptors at excitatory synapses in the hippocampus. This excludes a role for aspartate and, by extension, a recently proposed role for the sialic acid transporter sialin in excitatory transmission.
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