期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 24, 期 6, 页码 1089-1093出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2013.02.008
关键词
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资金
- National Science Foundation Graduate Research Fellowship
- Achievement Rewards for College Scientist (ARCS) Foundation - Chicago Chapter
- Chicago Biomedical Consortium
- Searle Funds at The Chicago Community Trust
- Searle Funds at Northwestern University
Vaccines based on virus-like particles have proved their success in human health. More than 25 years after the approval of the first vaccine based on this technology, the substantial efforts to expand the range of applications and target diseases are beginning to bear fruit. The incursion of high-throughput screening technologies, combined with new developments in protein engineering and chemical coupling, have accelerated the development of systems capable of producing macrostructures useful for vaccinology, gene delivery, immunotherapy and bionanotechnology. This review summarizes the most recent developments in microbial cell factories and cell-free systems for virus-like particle production and discusses the future impact of this technology in human and animal health.
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