期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 23, 期 5, 页码 718-726出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2011.12.025
关键词
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资金
- German Federal Ministry of Education and Research (BMBF) within the initiative Bioindustry21 [0315239A]
With a world market of more than four million tons per year, L-amino acids are among the most important products in industrial biotechnology. The recent years have seen a tremendous progress in the development of tailor-made strains for such products, intensively driven from systems metabolic engineering, which upgrades strain engineering into a concept of optimization on a global scale. This concept seems especially valuable for efficient amino acid production, demanding for a global modification of pathway fluxes - a challenge with regard to the high complexity of the underlying metabolism, superimposed by various layers of metabolic and transcriptional control.
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