期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 22, 期 4, 页码 566-575出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2011.04.016
关键词
-
资金
- SystemsX.ch
After about ten years of research renaissance in metabolism, the present challenge is to understand how metabolic fluxes are controlled by a complex interplay of overlapping regulatory mechanisms. Reconstruction of various regulatory network topologies is steaming, illustrating that we underestimated the broad importance of post-translational modifications such as enzyme phosphorylation or acetylation for microbial metabolism. With the growing topological knowledge, the functional relevance of these regulatory events becomes an even more pressing need. A major knowledge gap resides in the regulatory network of protein-metabolite interactions, simply because we lacked pertinent methods for systematic analyses - but a start has now been made. Perhaps most dramatic was the conceptual shift in our perception of metabolism from an engine of cellular operation to a generator of input and feedback signals for regulatory circuits that govern many important decisions on cell proliferation, differentiation, death, and naturally metabolism.
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