期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 21, 期 1, 页码 100-113出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2010.01.002
关键词
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资金
- Helmholtz Centre for Environmental Research (UFZ)
- Deutsche Forschungsgemeinschaft (DFG)
- European Union
- Free State of Saxony
Heterogeneity of industrial production cultures is accepted to a certain degree, however, the underlying mechanisms are seldom perceived or included in the development of new bioprocess control strategies Population heterogeneity and its basics, perceptible in the diverse proficiency of cells, begins with asymmetric birth and is found to recess during the life cycle Since inefficient subpopulations have significant impact on the productivity of industrial cultures, cellular heterogeneity needs to be detected and quantified by using high speed detection tools like flow cytometry. Possible origins of population heterogeneity, sophisticated fluorescent techniques for detection of individual cell states, and cutting-edge Omics-technologies for extended information beyond the resolution of fluorescent labelling are highlighted.
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