期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 21, 期 5, 页码 697-703出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.copbio.2010.06.008
关键词
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资金
- National Institutes of Health and National Academies Keck Futures Initiative
- National Science Foundation
- American Cancer Society
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI072453] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R00GM081450] Funding Source: NIH RePORTER
Minimal cells comprise only the genes and biomolecular machinery necessary for basic life. Synthesizing minimal and minimized cells will improve understanding of core biology, enhance development of biotechnology strains of bacteria, and enable evolutionary optimization of natural and unnatural biopolymers. Design and construction of minimal cells is proceeding in two different directions: 'top-down' reduction of bacterial genomes in vivo and 'bottom-up' integration of DNA/RNA/protein/membrane syntheses in vitro. Major progress in the past 5 years has occurred in synthetic genomics, minimization of the Escherichia coli genome, sequencing of minimal bacterial endosymbionts, identification of essential genes, and integration of biochemical systems.
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