期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 21, 期 3, 页码 292-297出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2010.03.003
关键词
-
资金
- US Department of Energy, Office of Basic Energy Sciences
- US National Institutes of Health
Decades of biophysical study on the hydrogenase (H(2)ase) enzymes have yielded sufficient information to guide the synthesis of analogs of their active sites. Three families of enzymes serve as inspiration for this work: the [FeFe]-H(2)ases, [NiFe]-H(2)ases, and [Fe]-H(2)ases, all of which feature iron centers bound to both CO and thiolate. Artificial H(2)ases affect the oxidation of H-2 and the reverse reaction, the reduction of protons. These reactions occur via the intermediacy of metal hydrides. The inclusion of amine bases within the catalysts is an important design feature that is emulated in related bioinspired catalysts. Continuing challenges are the low reactivity of H-2 toward biomimetic H(2)ases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据