期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 20, 期 1, 页码 63-73出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2009.02.006
关键词
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资金
- National Science Foundation
- HHMI
- Keaton-Raphael Memorial Gift Fund
- Americal Heart Association
- National Institutes of Health, National Cancer Institute [1U54C136465-01]
- National Center for Research Resources (NCRR) [UL1 RR024146]
- National Institutes of Health (NIH)
- NIH Roadmap for Medical Research
- Div Of Biological Infrastructure
- Direct For Biological Sciences [0852891] Funding Source: National Science Foundation
The gold standard for clinical diagnostics of tissues is immunofluorescence staining. Toxicity of many fluorescent dyes precludes their application in vivo. Raman spectroscopy, a chemically specific, label-free diagnostic technique, is rapidly gaining acceptance as a powerful alternative. It has the ability to probe the chemical composition of biological materials in a non-destructive and mostly non-perturbing manner. We review the most recent developments in Raman spectroscopy in the life sciences, detailing advances in technology that have improved the ability to screen for diseases. Its role in the monitoring of biological function and mapping the cellular chemical microenvironment will be discussed. Applications including endoscopy, surface-enhanced Raman scattering (SERS), and coherent Raman scattering (CRS) will be reviewed.
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