期刊
CURRENT ONCOLOGY
卷 22, 期 1, 页码 E11-E19出版社
MULTIMED INC
DOI: 10.3747/co.22.2150
关键词
Pancreatic cancer; tumour-associated macrophages; lymph node metastasis; neural invasion
类别
资金
- National Natural Science Foundation of China [81072045, 81302140]
- Medical Science Foundation of Guangdong Province [A2014262]
- Medical Science Foundation of Sun Yat-sen University [14ykpy29]
- Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes, Sun Yat-sen University [KLB09001]
- Key Laboratory of Malignant Tumor Molecular Mechanism and Translational Medicine of Guangzhou Bureau of Science and Information Technology [[2013]163]
Background We aimed to characterize the localization and prognostic significance of tumour-associated macrophages (TAMS) in pancreatic ductal adenocarcinoma (PDAC). Methods Tumour specimens from 70 patients with PDAC and inflammatory specimens from 13 patients with chronic pancreatitis were collected and analyzed for TAM and M2 macrophage counts by immunohistochemistry. Correlations between TAM distributions and clinicopathologic features were determined. Results Immunohistochemical analysis showed that TAM and M2 macrophage counts were higher in tissues from PDAC than from chronic pancreatitis. The TAMS and M2 macrophages both infiltrated more into peritumour. Both macrophage types were positively associated with lymph node metastasis (p = 0.041 for TAMS in peritumour, p = 0.013 for M2 macrophages in introtumour, p = 0.006 for M2 macrophage in peritumour). In addition, abdominal pain was significantly more frequent in PDAC patients with a greater TAMS count. The survival rate was much lower in patients having high infiltration by M2 macrophages than in those having low infiltration. Conclusions The TAM count might be associated with neural invasion in PDAC, and M2 macrophages might play an important role in lymph node metastasis. Higher counts of either macrophage type were associated with increased risk of lymph node metastasis, and the M2 macrophage count could potentially be a marker for evaluating prognosis.
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