期刊
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
卷 11, 期 2, 页码 211-217出版社
SPRINGER
DOI: 10.1007/s11910-010-0163-x
关键词
Sleep; Circadian rhythms; Huntington's disease; Hypothalamus; Actiwatch; Polysomnography; Actigraphy; Questionnaires
资金
- Medical Research Council [G0800784] Funding Source: Medline
- MRC [G0800784] Funding Source: UKRI
- Medical Research Council [G0800784, G0800784B] Funding Source: researchfish
Huntington's disease (HD) is a fatal neurodegenerative disease characterized by motor, cognitive, and psychiatric disturbance. In this article, we used polysomnography, actigraphy and a variety of validated questionnaires to ascertain the extent to which sleep changes are identifiable and measurable in mild stage HD, and importantly, to see whether patients are negatively impacted by the changes in their sleep. We found significant differences in sleep architecture and sleep efficiency in patients compared with controls using polysomnography. However, patient scores on the Functional Outcomes of Sleep Questionnaire, Medical Outcomes of Sleep Scale, and Epworth Sleepiness Scale were not significantly different to controls. These results suggest that although marked changes in sleep architecture are present in early HD and can be detected using polysomnography, patients do not necessarily recognize or report these abnormalities.
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