期刊
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
卷 10, 期 5, 页码 359-366出版社
SPRINGER
DOI: 10.1007/s11910-010-0122-6
关键词
Alzheimer's Disease; Dementia; Estrogen; Hormone Replacement Therapy; Genetics
资金
- Charles L. and Ann Lee Saunders Brown Fellowship
- National Institutes of Health (NIH) [5 T32 MH2004, R01AG014673, P01HD035897, P01AG07232, R01AG028786, U01 AG023749, P50 AG08702, R01AG007370, R21CA125461, R01AG036040, AG034189]
- Alzheimer's Association [IIRG-08-90655, IIRG-08-92010]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P01HD035897, U54HD079123] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [R21CA125461] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [T32MH020048, T32MH020004] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [U01AG023749, R01AG014673, P01AG007232, P50AG008702, R01AG034189, R56AG034189, R01AG028786, R01AG007370, R01AG036040] Funding Source: NIH RePORTER
Research increasingly suggests that changes in estrogen levels during aging may increase the risk of Alzheimer's disease, the most common type of dementia. This update reviews the newest information about estrogen and cognitive aging, including information regarding the role of bioavailable estrogen in older women and men, use of selective estrogen receptor modulators to improve cognition, and studies of genetic risk factors to elucidate the effects of endogenous estrogen on aging and cognition. Future trials are needed to determine whether alternate timing, dosage, formulation, or method of administration of hormone replacement can reduce the risk of dementia.
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