期刊
CURRENT MOLECULAR MEDICINE
卷 14, 期 5, 页码 630-651出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1566524014666140603101953
关键词
Apoptosis; cell adherence; galectins; immune regulation; oncogenesis; signaling pathways
资金
- Agencia Nacional de Promocion Cientifica y Tecnica
- Fundacion Fiorini
- Association pour la Recherche Sur Les Tumeurs de la Prostate (ARTP)
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
Galectins control cell behavior by acting on different signaling pathways. Most of the biological activities ascribed to these molecules rely upon recognition of extracellular glycoconjugates and establishment of multivalente interactions, which trigger adaptive biological responses. However, galectins are also detected within the cell in different compartments, where their regulatory functions still remain poorly understood. A deeper understanding of the entire galectin signalosome and its impact in cell behavior is therefore essential in order to delineate new strategies to specifically manipulate both galectin expression and function. This review summarizes our current knowledge of the signaling pathways activated by galectins, their glycan dependence and the cellular compartment where they become activated and are biologically relevant.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据