期刊
CURRENT MOLECULAR MEDICINE
卷 14, 期 2, 页码 255-274出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1566524014666140128112827
关键词
Cancer progression; Caveolin-1 (CAV1); invasion; metastasis; migration; phosphorylation; tyrosine-14
资金
- FONDECYT [1130250]
- CONICYT-FONDAP [15130011]
- Anillo grant [ACT1111]
- CONICYT
Caveolin-1 is a member of the caveolin family that has been ascribed a dual role in cancer. In early stages of disease the protein functions predominantly as a tumor suppressor, whereas at later stages, caveolin-1 expression is associated with tumor progression and metastasis. Here, some mechanisms associated with caveolin-1-dependent tumor suppression will be briefly discussed before focusing on the role of this protein and particularly phosphorylation of tyrosine-14 in promoting cell migration, invasion and metastasis. Models are provided summarizing possible explanations for these dramatic changes in function, as well as mechanisms by which this may be achieved.
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