期刊
CURRENT MOLECULAR MEDICINE
卷 12, 期 5, 页码 625-633出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156652412800620039
关键词
Acute phase protein; cerebral ischemic injury; DAMP; endotoxemia; HMGB1; innate immune cells; PAMP; sepsis
资金
- National Institute of General Medical Sciences [R01GM063075, R01GM070817]
- National Center of Complementary & Alternative Medicine [R01AT05076]
Infection and injury are two seemingly unrelated processes that often converge on common innate inflammatory responses mediated by pathogen- or damage-associated molecular patterns (PAMPs or DAMPs). If dysregulated, an excessive inflammation manifested by the overproduction and release of proinflammatory mediators (e.g., TNF, IFN-gamma, and HMGB1) may adversely lead to many pathogenic consequences. As a counter-regulatory mechanism, the liver strategically re-prioritizes the synthesis and systemic release of acute phase proteins (APP) including the fetuin-A (also termed alpha-2-HS-glycoprotein for the human homologue). Fetuin-A is divergently regulated by different proinflammatory mediators, and functions as a positive or negative APP in injury and infection. It not only facilitates anti-inflammatory actions of cationic polyamines (e.g., spermine), but also directly inhibits PAMP-induced HMGB1 release by innate immune cells. Peripheral administration of fetuin-A promotes a short-term reduction of cerebral ischemic injury, but confers a long-lasting protection against lethal endotoxemia. Furthermore, delayed administration of fetuin-A rescues mice from lethal sepsis even when the first dose is given 24 hours post the onset of disease. Collectively, these findings have reinforced an essential role for fetuin-A in counter-regulating injury-or infection-elicited inflammatory responses.
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