期刊
CURRENT MOLECULAR MEDICINE
卷 12, 期 3, 页码 259-267出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156652412799218903
关键词
Alzheimer's disease; autoimmunity; costimulation; HIV infection; immune tolerance; multiple sclerosis; PD-1; PD-L1; T-cell activation
T-cell activation is dependent on signals delivered through the antigen-specific T-cell receptor and accessory receptors on T-cells. Integration of signals through this family of costimulatory and inhibitory receptors and their ligands regulates the balance between T-cell activation, tolerance, and immunopathology. Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, deliver inhibitory signals and exert a vital and diverse range of immunoregulatory roles in T-cell activation, tolerance, and immune-mediated tissue damage. In this review, we revisit current understanding of the immunoregulatory functions of PD-1 and its ligands and their involvement in immune-mediated diseases.
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