期刊
JOURNAL OF NEUROPHYSIOLOGY
卷 113, 期 3, 页码 709-719出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00828.2014
关键词
arousal; bipolar disorder; P/Q-type calcium channels; REM sleep; schizophrenia; waking
资金
- National Institutes of Health (NIH) [R01-NS-020246]
- NIH [P20-GM-103425, P30-GM-110702]
- FONCYT-Agencia Nacional de Promocion Cientifica y Tecnologica [BID 1728 OC.AR]
- [PICT 2008-2019]
- [PICT-2012-1769]
Reduced levels of gamma-band activity are present in schizophrenia and bipolar disorder patients. In the same disorders, increased neuronal calcium sensor protein-1 (NCS-1) expression was reported in a series of postmortem studies. These disorders are also characterized by sleep dysregulation, suggesting a role for the reticular activating system (RAS). The discovery of gamma-band activity in the pedunculopontine nucleus (PPN), the cholinergic arm of the RAS, revealed that such activity was mediated by high-threshold calcium channels that are regulated by NCS-1. We hypothesized that NCS-1 normally regulates gamma-band oscillations through these calcium channels and that excessive levels of NCS-1, such as would be expected with overexpression, decrease gamma-band activity. We found that PPN neurons in rat brain slices manifested gamma-band oscillations that were increased by low levels of NCS-1 but suppressed by high levels of NCS-1. Our results suggest that NCS-1 overexpression may be responsible for the decrease in gamma-band activity present in at least some schizophrenia and bipolar disorder patients.
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