期刊
CURRENT MICROBIOLOGY
卷 60, 期 4, 页码 263-267出版社
SPRINGER
DOI: 10.1007/s00284-009-9535-3
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资金
- Consejo Nacional de Ciencia y Tecnologia from Mexico (CONACyT) [43644, 84482]
- NASA [NNA06CB58G]
- USDA [FLA-MCS-04602]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0843606] Funding Source: National Science Foundation
The role played by the Y-family DNA polymerases YqjH and YqjW in protecting sporulating cells of Bacillus subtilis from DNA damage was determined. The absence of either yqjH and/or yqjW not only reduced sporulation efficiency but also sensitized the sporulating cells to hydrogen peroxide, tert-butylhydroperoxide (t-BHP), mitomycin-C (M-C), and UV-C radiation. Moreover, these DNA-damaging agents increased the mutation frequency of wild-type sporulating cells to 4-azaleucine, but the production of mutants was YqjH- and YqjW-dependent. In conclusion, the results presented here indicate that YqjH/YqjW-dependent-translesion synthesis (TLS) operates in sporulating B. subtilis cells and contributes in processing spontaneous and artificially induced genetic damage, which is apparently required for an efficient sporulation process.
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