期刊
CURRENT MEDICINAL CHEMISTRY
卷 21, 期 22, 页码 2497-2509出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867321666131212152408
关键词
Bioprinting; cardiac microtissues; cell encapsulation; cell microenvironment; drug screening; high throughput; hydrogels; stem cells; three dimensional; tissue engineering
资金
- Major International Joint Research Program of China [11120101002]
- National 111 Project of China [B06024]
- Key (Key grant) Project of Chinese Ministry of Education [313045]
- National Natural Science Foundation of China [11372243, 81301040]
- South Wisdom Valley Innovative Research Team Program
- National Basic Research Program of China (973 Program) [2011CB707704]
- National instrumentation program of China [2013YQ190467]
- International Science & Technology Cooperation Program of China [2013DFG02930]
- China Postdoctoral Science Foundation [2013M532054, 2013M540742]
- China Young 1000-Talent Program
- Shaanxi 100-Talent Program
Heart disease is one of the major global health issues. Despite rapid advances in cardiac tissue engineering, limited successful strategies have been achieved to cure cardiovascular diseases. This situation is mainly due to poor understanding of the mechanism of diverse heart diseases and unavailability of effective in vitro heart tissue models for cardiovascular drug screening. With the development of microengineering technologies, three-dimensional (3D) cardiac microtissue (CMT) models, mimicking 3D architectural microenvironment of native heart tissues, have been developed. The engineered 3D CMT models hold greater potential to be used for assessing effective drugs candidates than traditional two-dimensional cardiomyocyte culture models. This review discusses the development of 3D CMT models and highlights their potential applications for high-throughput screening of cardiovascular drug candidates.
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