期刊
CURRENT MEDICINAL CHEMISTRY
卷 21, 期 22, 页码 2469-2479出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867321666131212152637
关键词
Anti-Cancer; drug delivery; growth factors; hormones; nanomedicine; nucleic acids; peptide amphiphiles; proteins; self-assembly; therapeutics
资金
- National University of Singapore [R279000328112, R279000353112]
The use of nanobiotechnology in the formulation of drug carriers has been gaining popularity in recent years. Peptide self-assembly technology is a particularly attractive option due to its simplicity and programmability. Self-assembling peptide amphiphiles are surfactant-like molecules that are capable of spontaneous organization into a variety of nanostructures. The structural and functional features of these nanostructures can be designed through alterations to the peptide sequence. With a keen understanding of the supramolecular principles governing the non-covalent interactions involved, drug loading strategies can be customised. Hydrophobic drugs can be hidden within the core via aromatic interactions while gene-based therapeutics can be complexed with a cationic region of lysine residues. This review article focuses on the application of self-assembling peptide amphiphiles to drug delivery in the area of anti-cancer therapeutics, protein-and peptide-based therapeutics and nucleic acid-based therapeutics. Specific examples are used to discuss the various systems available and emphasis is given to the encapsulation and release mechanism.
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