期刊
CURRENT MEDICINAL CHEMISTRY
卷 19, 期 26, 页码 4451-4461出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986712803251548
关键词
Peptide; drug delivery; vaccine; manufacture; bioavailability; peptide therapeutic; immunogenicity; peptide drug; peptide synthesis; clinical trials
资金
- Australian Research Council [DP110100212, DP1092829]
- Australian Research Council [DP1092829] Funding Source: Australian Research Council
The development of techniques for efficient peptide production renewed interest in peptides as therapeutics. Numerous modifications for improving stability, transport and affinity profiles now exist. Several new adjuvant and carrier systems have also been developed, enhancing the immunogenicity of peptides thus allowing their development as vaccines. This review describes the established and experimental approaches for manufacturing peptide drugs and highlights the techniques currently used for improving their drug like properties.
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