期刊
CURRENT MEDICINAL CHEMISTRY
卷 19, 期 34, 页码 5819-5836出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986712804143268
关键词
Amidines; 1,5-bis(4-amidinophenoxy) pentane; amidinoximes; benzimidazoles; diamidines; furamidines; human african try-panosomiasis (HAT); leishmania; nitriles; pentamidine analogues; pneumocystis carinii pneumomia; trypanosoma brucei
资金
- We are grateful for the financial support from Regione Autonoma della Sardegna (Sintesi e caratterizzazione delle proprieta chimiche e degli effetti neuromodulatori sul SNC di una libreria di donatori di nitrossido derivati dall'acido di Piloty)
Sixty years after its introduction, 1,5-bis(4-amidinophenoxy)pentane (Pentamidine) is still one of the most used drugs for the treatment of the first stage of Human African trypanosomiasis and other neglected diseases such as malaria and leishmaniasis. These protozoan infections are prevalent in the poorest world areas such as sub-saharian and developing countries, however the increasing immigration from these countries to the richest part of the world and the overlap of HIV with parasitic infections result in a growing number of cases in developed nations. A great effort has been made to develop new generations of diamidines for the treatment of these infections transmitted by insects. This review summarises the synthesis and evaluation of pentamidine analogues reported in the last years in the effort to find new drugs with better pharmaceutical activity, higher lipophilicity and lower citotoxycicty.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据