期刊
CURRENT MEDICINAL CHEMISTRY
卷 18, 期 27, 页码 4185-4194出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986711797189547
关键词
Aptamers; drug delivery; cancer; nanomedicine; theranostics; RNA interference; siRNA
资金
- University of Wisconsin Carbone Cancer Center, NCRR [1UL1RR025011]
- DOD
Cancer is one of the leading causes of death around the world. Tumor-targeted drug delivery is one of the major areas in cancer research. Aptamers exhibit many desirable properties for tumor-targeted drug delivery, such as ease of selection and synthesis, high binding affinity and specificity, low immunogenicity, and versatile synthetic accessibility. Over the last several years, aptamers have quickly become a new class of targeting ligands for drug delivery applications. In this review, we will discuss in detail about aptamer-based delivery of chemotherapy drugs (e. g. doxorubicin, docetaxel, daunorubicin, and cisplatin), toxins (e. g. gelonin and various photodynamic therapy agents), and a variety of small interfering RNAs. Although the results are promising which warrants enthusiasm for aptamer-based drug delivery, tumor homing of aptamer-based conjugates after systemic injection has only been achieved in one report. Much remains to be done before aptamer-based drug delivery can reach clinical trials and eventually the day-to-day management of cancer patients. Therefore, future directions and challenges in aptamer-based drug delivery are also discussed.
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