期刊
CURRENT MEDICINAL CHEMISTRY
卷 18, 期 4, 页码 523-538出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986711794480221
关键词
Combretastatin A-4; Tubulin inhibitors; Anticancer; Antineoplastic Agents; Structure-Activity Relationships
资金
- National Natural Science Foundation (NNSF) of China [30901839, 30873134]
- Intramural Research Foundation of Xi'an Jiaotong University [xjj2009073]
Tubulin protein is one of several members of a small family of globular proteins. It offers a potential target for anticancer drug design and development. Combretastatin A-4 (CA-4) is a potent anticancer and antiangiogenesis natural substance isolated from Combretum caffrum. Modifications on the CA-4 structure have led to a great number of novel CA-4 derivatives as potent tubulin inhibitors and high cytotoxic anticancer agents is becoming an interesting field, leading to a breakthrough in the treatment of cancer. In this review, the recent developments of novel CA-4 derivatives via the modifications on the A-and B-ring and the double bond as anticancer agents are discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据