期刊
CURRENT MEDICINAL CHEMISTRY
卷 17, 期 26, 页码 2967-2978出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986710792065027
关键词
Adamantane; hydrophobic effects; ion channels; rigid scaffold
资金
- Vicerrectoria de Investigacion
- Escuela de Quimica
- Centro de Investigaciones en Productos Naturales at the Universidad de Costa Rica
This review summarizes the importance and recent discoveries of the use of adamantane derivatives in Medicinal Chemistry. We have organized the article in 4 sections: 1) Absorption, Distribution, Metabolism, or Excretion (ADME) properties 2) Hydrophobic Effects 3) Ion Channels and 4) Rigid scaffold. Within each section, we have provided examples of how the adamantane group changes the properties of known drugs or provides a important pharmacophore for the design of new drugs.
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