期刊
CURRENT MEDICINAL CHEMISTRY
卷 17, 期 3, 页码 264-289出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986710790149729
关键词
Aminophosphonic acids; Aminophosphonates; Synthesis; Asymmetric synthesis; Biological activity
资金
- MIUR (Ministero dell'Istruzione, dell'Universita e della Ricerca)
- Universita degli Studi di Milano
- Universita dell' Insubria
In recent years, phosphonic acids and their derivatives have received increasing attention as analogues of a series of naturally occurring phosphates and as bio-isosteric phosphorus analogues of aminoacids. Unlike a phosphate group, the phosphonate moiety is not readily hydrolyzed, in a biological environment, by the enzymes involved in the phosphate cleavage. This feature makes these compounds extremely useful in several applications, in metabolic regulation, in enhancement or inhibition studies, in the development of potential drugs against several metabolic disorders. The great potential of these compounds in biological applications resulted in an intense effort directed to the development of efficient synthetic methods for their preparation, with particular attention to stereoselective synthesis. The purpose of this review is to give an up-to-date account of the chemistry, the synthesis and the biological activity of aminophosphonic acids and their derivatives.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据