期刊
CURRENT MEDICINAL CHEMISTRY
卷 16, 期 21, 页码 2641-2652出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986709788681994
关键词
Endothelium; lipids; reactive oxygen species; atherosclerosis; scavenger receptors; Class E; angiotensin II; hydroxymethylglutaryl-CoA reductase inhibitors; cytokines
资金
- Arthritis Foundation
- National Institutes of Health [HL073814]
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a scavenger receptor that primarily binds and regulates oxidized low-density lipoprotein (LDL). Expression of LOX-1 is regulated by a feed-forward system stimulated by oxidized LDL (oxLDL), a major component of atherosclerosis. LOX-1 is a homodimer with a reactive backbone that can bind to a host of different ligands, including small molecules, and whole cells. LOX-1 is involved in many intercellular, intracellular, and molecular processes that are atherogenic. LOX-1 levels are elevated within atherosclerotic plaques and its expression is induced by proinflammatory cytokines. The ability of LOX-1 to bind many different ligands and control several atherogenic processes makes this receptor a likely vascular disease biomarker as well as an ideal choice for drug therapy aimed at preventing cardiovascular disease.
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