期刊
CURRENT MEDICINAL CHEMISTRY
卷 16, 期 2, 页码 203-217出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986709787002763
关键词
Postprandial lipemia; statins; fibrates; chylomicron; chylomicron remnant; triglyceride-rich lipoprotein; remnant-like particle; apolipoproteins
Postprandial lipemia has emerged as an independent risk factor for coronary artery disease. In this systematic review we examined the effect of the medications used for the management of dyslipidemia on postprandial lipemia. Statins, beyond their effects on fasting lipid levels, reduce also postprandial lipemia mainly by inhibiting the production of apoB containing lipoproteins from the liver and thus increasing the clearance of triglyceride-rich lipoproteins of either liver or intestinal origin. Fibrates decrease fasting triglyceride and increase high density lipoprotein cholesterol levels. Besides, fibrates are particularly potent drugs in the reduction of postprandial lipemia; they decrease the production or triglyceride-rich lipoproteins and increase their clearance by enhancing the activity of lipoprotein lipase.
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