期刊
CURRENT MEDICINAL CHEMISTRY
卷 15, 期 27, 页码 2826-2839出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986708786242778
关键词
Polyethylenimine; polymer; DNA; transfection; gene therapy; drug delivery; medicinal chemistry; biomedical applications
Polyethylenimine (PEI), an organic branched or linear polyamine polymer, has been successfully used in the past for DNA complexation and transfection in vitro and in vivo into several cell lines and tissues. PEI was also applied in different fields from gene therapy and several studies have emphasized the importance of this polymer in medicinal chemistry. In this brief critical review the uses and applications of this versatile polymeric molecule will be discussed.
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