期刊
CURRENT MEDICINAL CHEMISTRY
卷 15, 期 26, 页码 2656-2663出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986708786242903
关键词
membrane fluidity; membrane lipid rafts; acid sphingomyelinase; Fas death receptor; Na+/H+ exchanger 1 (NHE1); DNA adducts
资金
- la Ligue Nationale Contre le Cancer (the Morbihan, Cote d'Armor and Ille et Vilaine Comittees)
- Rennes Metropole and la Region Bretagne
Most current anticancer therapies induce tumor cell death through apoptosis where its specific involved pathways are poorly understood. For example, for many DNA-damaging agents, the specific biochemical lesions (DNA adducts) are associated with the induction of apoptosis via the mitochondria death pathway. However, several of these DNA-damaging agents like cisplatin induce apoptosis through plasma membrane disruption, triggering the Fas death receptor pathway. In this review, we focus on the role of early plasma membrane events in cisplatin-induced apoptosis. Special attention is given to changes in plasma membrane fluidity, inhibition of NHE1 exchanger, activation of acid sphingomyelinase and their consequences on the Fas death pathway in response to cisplatin.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据