期刊
CURRENT MEDICINAL CHEMISTRY
卷 15, 期 22, 页码 2192-2222出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986708785747490
关键词
Matrix metalloproteinases; Enzyme-substrate recognition; Enzyme-inhibitor recognition; Structural bases
资金
- Italian Ministery of University and Research (MiUR) [COFIN 2003058409, FIRB RBNE03PX83, COFIN 2006068412_003]
- Italian Space Agency
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases which are involved in the proteolytic processing of several components of the extracellular matrix. As a consequence, MMPs are implicated in several physiological and pathological processes, like skeletal growth and remodelling, wound healing, cancer, arthritis, and multiple sclerosis, raising a very widespread interest toward this class of enzymes as potential therapeutic targets. Here, structure-function relationships are discussed to highlight the role of different MMP domains on substrate/inhibitor recognition and processing and to attempt the formulation of advanced guidelines, based on natural substrates, for the design of inhibitors more efficient in vivo.
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