期刊
CURRENT MEDICINAL CHEMISTRY
卷 15, 期 8, 页码 779-785出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986708783955545
关键词
virus; membrane; peptide; fusion; receptor tyrosine kinase; HIV; SFFV; BPV
Viral proteins sometimes interfere with human transmembrane receptors to gain access into a cell or they use transmembrane domains to interfere with cellular signal cascades in human cells. Such interference can lead to a deregulation of tightly regulated processes and eventually to different forms of cancer. There is still little knowledge about how proteins act and interact in biological membranes but the membrane environment restricts the fold and composition of membrane proteins when compared to water soluble proteins. These restrictions and a sometimes related functional principle of different viral transmembrane proteins for gaining access to a host cell or to intervene with cellular processes may offer a great opportunity to interfere with those processes in a simplified manner. A close collaboration of various disciplines may result in the development of drugs that specifically target membranes and interfere with viral transmembrane domains or even regulate the function of cellular membrane proteins. In this review we describe the function of interactions between human and viral membrane proteins in a cellular membrane, and perspectives to intervene with those processes are discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据