期刊
CURRENT MEDICINAL CHEMISTRY
卷 15, 期 7, 页码 711-715出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986708783885309
关键词
preeclampsia; sFlt-1; PlGF; VEGF; hypoxia
Despite its clinical importance, the mechanism of preeclampsia is unclear; however, many believe placental pathology might be related to maternal systemic disease. If this is true, a factor which mediates information from the placenta to the maternal circulation can be hypothesized. Among a variety of such reported factors, soluble fms-like tyrosine kinase-1 (sFlt1) will be the focus of this review. The hypoxic placenta, which is commonly found in preeclampsia, produces sFlt1; furthermore, animal experiments suggest its overexpression leads to preeclampsia-like symptoms.
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