期刊
CURRENT HYPERTENSION REPORTS
卷 20, 期 11, 页码 -出版社
SPRINGER
DOI: 10.1007/s11906-018-0892-9
关键词
Blood pressure; Salt; Skin; Sodium; VEGF-C
资金
- British Heart Foundation
- Addenbrookes Charitable Trust
- NIHR
Purpose of ReviewDietary sodium is an important trigger for hypertension and humans show a heterogeneous blood pressure response to salt intake. The precise mechanisms for this have not been fully explained although renal sodium handling has traditionally been considered to play a central role.Recent FindingsAnimal studies have shown that dietary salt loading results in non-osmotic sodium accumulation via glycosaminoglycans and lymphangiogenesis in skin mediated by vascular endothelial growth factor-C, both processes attenuating the rise in BP. Studies in humans have shown that skin could be a buffer for sodium and that skin sodium could be a marker of hypertension and salt sensitivity.SummarySkin sodium storage could represent an additional system influencing the response to salt load and blood pressure in humans.
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