期刊
CURRENT HYPERTENSION REPORTS
卷 10, 期 2, 页码 93-98出版社
SPRINGER
DOI: 10.1007/s11906-008-0019-9
关键词
-
资金
- NHLBI NIH HHS [R01 HL082791-02, R01 HL073085-02, R01 HL073085-05, R01 HL082791, R01 HL073085-04, R01 HL073085-03, R01 HL073085, R01 HL082791-03, R01 HL082791-01A1, R01 HL073085-01] Funding Source: Medline
- NINDS NIH HHS [R01 NS039774-05, R01 NS039774-07, R01 NS039774-01A1, R01 NS039774-04A3, R01 NS039774-03, R01 NS039774-02, R01 NS039774-06] Funding Source: Medline
A local renin-angiotensin system (RAS) has been proposed in adipocytes. Adipocytes are a suggested source of components of the RAS, with regulation of their production related to obesity-hypertension. Both angiotensin type 1 and 2 receptors have been localized to adipocytes. Angiotensin II has been demonstrated to regulate adipocyte growth and differentiation, lipid metabolism, and expression and release of adipokines and RAS components, and to promote oxidative stress. Differences in regional expression of RAS components in visceral versus subcutaneous adipose tissue have been suggested as a link between abdominal obesity and cardiovascular disease. Finally, several studies support anti hypertensive efficacy of RAS blockade in patients with type 2 diabetes and obesity. Future studies should address the role of adipocyte-specific deficiency of RAS components to definitively determine the relevance of the adipose RAS to normal physiology and to the development of hypertension.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据