期刊
CURRENT HIV RESEARCH
卷 10, 期 5, 页码 469-477出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157016212802138805
关键词
Opioid; HAND; microglia; astrocyte; neuron; TLR; opportunistic infection
资金
- NIDA NIH HHS [K05 DA033881, R01 DA050542, T32 DA045734, R01 DA012104, R01 DA037843, R01 DA022935, R01 DA034582, P50 DA011806, R01 DA044582, R01 DA043252, R01 DA031202] Funding Source: Medline
Drug abuse and HIV infection are interlinked. From the onset of the HIV/AIDS epidemic, the impact of illicit drug use on HIV disease progression has been a focus of many investigations. Both laboratory-based and epidemiological studies strongly indicate that drug abuse may exacerbate HIV disease progression and increase mortality and morbidity in these patients. Increase susceptibility to opportunistic infection has been implicated as one of the major causes for this detriment. Furthermore, opioids are known to elicit prevalence of neurodegenerative disorders in HIV-infected patients. Numerous authors have delineated various molecular as well as cellular mechanisms associated with neurological complications in these patients. This review gives an overview of these findings. Understanding the mechanisms will allow for the development of targeted therapies aimed at reducing the progression of neurocognitive decline in the drug abusing HIV infected individuals.
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