期刊
CURRENT GENOMICS
卷 13, 期 7, 页码 519-532出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920212803251427
关键词
Mitochondria; Aging; Reactive oxygen species; Dietary restriction; Target of rapamycin (TOR)
资金
- World Class University program [R31-10100]
- National Junior research fellowship [2012-0000389]
- Basic Science Research Program [2012-0002294]
- Ministry of Education, Science and Technology through the National Research Foundation of Korea
Mitochondria are essential for various biological processes including cellular energy production. The oxidative stress theory of aging proposes that mitochondria play key roles in aging by generating reactive oxygen species (ROS), which indiscriminately damage macromolecules and lead to an age-dependent decline in biological function. However, recent studies show that increased levels of ROS or inhibition of mitochondrial function can actually delay aging and increase lifespan. The aim of this review is to summarize recent findings regarding the role of mitochondria in organismal aging processes. We will discuss how mitochondria contribute to evolutionarily conserved longevity pathways, including mild inhibition of respiration, dietary restriction, and target of rapamycin (TOR) signaling.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据