期刊
CURRENT GENETICS
卷 61, 期 2, 页码 115-125出版社
SPRINGER
DOI: 10.1007/s00294-014-0459-5
关键词
Aspergillus nidulans; Sulfur metabolism; bZIP transcription factor; Regulation
资金
- State Committee for Scientific Research/National Center of Science (NCN) [2762/B/P01/2009/37]
In Aspergillus nidulans, expression of sulfur metabolism genes is activated by the MetR transcription factor containing a basic region and leucine zipper domain (bZIP). Here we identified and characterized MetZ, a new transcriptional regulator in A. nidulans and other Eurotiales. It contains a bZIP domain similar to the corresponding region in MetR and this similarity suggests that MetZ could potentially complement the MetR deficiency. The metR and metZ genes are interrupted by unusually long introns. Transcription of metZ, unlike that of metR, is controlled by the sulfur metabolite repression system (SMR) dependent on the MetR protein. Overexpression of metZ from a MetR-independent promoter in a Delta metR background activates transcription of genes encoding sulfate permease, homocysteine synthase and methionine permease, partially complementing the phenotype of the Delta metR mutation. Thus, MetZ appears to be a second transcription factor involved in regulation of sulfur metabolism genes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据