期刊
CURRENT GENE THERAPY
卷 11, 期 6, 页码 457-465出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156652311798192879
关键词
Biocompatibility; gene therapy; polyplex nanomicelle; polycation; toxicity; non-viral gene delivery
Plasmid DNA (pDNA)-based gene therapy is a promising strategy for treating many chronic diseases and pathological states. Using pDNA has several advantages such as the sustained synthesis of proteins and peptides in their natives form, ease of the combined use of two or more bioactive factors, and cost-effectiveness. For effective pDNA delivery, cationic polymers are good candidates providing high pDNA stability and functionality. In this article, the development of polyplex nanomicelles composed of poly(ethyleneglycol) (PEG)-polycation block copolymers and pDNA as well as their future prospects is reviewed. The issues of safety and the transfection efficiency are highlighted for considerations of in vivo pDNA delivery.
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