期刊
CURRENT EYE RESEARCH
卷 34, 期 11, 页码 913-924出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/02713680903198045
关键词
Cell therapy; Conjunctiva; Ocular surface; Ocular surface reconstruction; Tissue engineering
资金
- Special Trustees of Moorfields Eye Hospital [SCHR 1210/1-1]
- Deutsche Forschun gsgemeinschaft (DFG)
- NIHR BMRC for Ophthal mology
- Moorfields Eye Hospital
- UCL Institute of Ophthalmology (JTD)
- Gertrud Kusen Stiftung
Reconstruction of the conjunctiva is an essential part of ocular surface regeneration, especially if an extensive area or the whole ocular surface is affected, such as in patients with ocular cicatricial pemphigoid, Stevens-Johnson syndrome, toxic epidermal necrolysis, or chemical/thermal burns. In these situations, corneal reconstruction almost inevitably fails unless the conjunctival surface is first repaired and a deep fornix is restored. The growing field of tissue engineering and advances in stem cell research offer promising new alternatives for these challenges. This article reviews the present approaches for reconstruction of the conjunctival surface, considering the established strategies and new potential methodologies.
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