期刊
CURRENT DRUG TARGETS
卷 14, 期 8, 页码 919-935出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/13894501113149990015
关键词
Age-related macular degeneration; diabetic retinopathy; hypoxia signaling; hypoxia-inducible factor-1 (HIF-1); ocular neovascularization; retinopathy of prematurity
资金
- NIH [R01EY09171, R01EY010659]
Constant oxygen supply is essential for proper tissue development, homeostasis and function of all eukaryotic organisms. Cellular response to reduced oxygen levels is mediated by the transcriptional regulator hypoxia-inducible factor-1 (HIF-1). It is a heterodimeric complex protein consisting of an oxygen dependent subunit (HIF-1 alpha) and a constitutively expressed nuclear subunit (HIF-1 beta). In normoxic conditions, de novo synthesized cytoplasmic HIF-1 alpha is degraded by 26S proteasome. Under hypoxic conditions, HIF-1 alpha is stabilized, binds with HIF-1 beta and activates transcription of various target genes. These genes play a key role in regulating angiogenesis, cell survival, proliferation, chemotherapy, radiation resistance, invasion, metastasis, genetic instability, immortalization, immune evasion, metabolism and stem cell maintenance. This review highlights the importance of hypoxia signaling in development and progression of various vision threatening pathologies such as diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration and glaucoma. Further, various inhibitors of HIF-1 pathway that may have a viable potential in the treatment of oxygen-dependent ocular diseases are also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据