期刊
CURRENT DRUG TARGETS
卷 14, 期 10, 页码 1150-1156出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/13894501113149990187
关键词
miR-223; Fbw7; apoptosis; cell growth; genistein; pancreatic cancer
资金
- NSFC [81172087]
- Natural Science Research key Project of Education Office of Anhui Province [KJ2012A196]
Although genistein has been shown to inhibit tumorigenesis in a variety of human cancers including pancreatic cancer (PC), the exact molecular mechanism of its anti-cancer effects has not yet been fully elucidated. Recently, microRNAs (miRNAs) have been reported to regulate multiple aspects of tumor development and progression, indicating that targeting miRNAs could be a novel strategy to treat human cancers. In the current study, we investigated whether a natural compound genistein could down-regulate onco-miR-223, resulting in the inhibition of cell growth and invasion, and induction of apoptosis in PC cells. We found that genistein treatment significantly inhibited miR-223 expression and up-regulated Fbw7, one of the targets of miR-223. Moreover, down-regulation of miR-223 inhibited cell growth and induced apoptosis in PC cells. These findings suggest that genistein exerts its anti-tumor activity partly through downregulation of miR-223 in PC cells.
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